Products

Benefits of breast milk

Medications and breastfeeding

Time to read: 2 min.

Breastfeeding mums can safely use most prescribed medications. It is well known that most medications transfer into milk to an extent, however, most do so in levels which are not hazardous to the baby. Nonetheless, doctors and pharmacists should be notified that a mother is breastfeeding prior to prescribing her a particular medication.

Drugs may transfer into milk if they reach high concentrations in maternal plasma, are low in molecular weight (<800 Da), are low in protein binding and pass easily into the brain. Other factors, such as the oral bioavailability of the medication to the baby, are also very important. Many medications, for instance, can be destroyed in the baby’s gut or are stored in the mother’s liver, and may never reach the mother’s plasma.

Drugs can enter milk by passive diffusion from the maternal plasma compartment and the maternal milk compartment. Medications normally pass from maternal plasma into the lactocytes, but they must pass through both bilayer lipid membranes of the lactocytes to reach the milk. During the first three days post-partum, however, tight junctions between lactocytes can be open and permit enhanced drug transfer into the milk.

Medications that inhibit milk production

Drug-related inhibition of milk production may occur via inhibition of prolactin from the pituitary, inhibition of oxytocin release and via direct effects on lactocytes. A comprehensive list of drugs and medications that may inhibit milk production can be found at https://www.ncbi.nlm.nih.gov/books

General guidelines for most medications and drugs during breastfeeding

  • Avoid using medications unless necessary, including herbal drugs
  • Most medications are suitable if the relative baby dose is less than 10 per cent, however, consultation with a medical professional is advised
  • Safe medications while breastfeeding generally should have short half-lives, high protein binding, low oral bioavailability in the baby and high molecular weight
  • Medical professionals should refer to an up-to-date database of drug interactions which can occur during lactation before prescribing a new drug to breastfeeding mums.
References

Hale, T., Hartmann, P.E., editors. Hale and Hartmann's textbook of human lactation. Amarillo, Tx: Hale Publishing; 2007.

Hale T., and Rowe, H.E., Medications in Mother’s Milk. 16ed. Amarillo, Tx: Hale Publishing 2014.

Related Articles

Articles that may be of interest

Breastfeeding

Reasons for blocked ducts

Read more
NICU

Ensure a successful transition from hospital to home

Read more
Pumping

Storing and thawing breast milk

Read more
Breastfeeding

Reasons for blocked ducts

Read more
NICU

Ensure a successful transition from hospital to home

Read more
Pumping

Storing and thawing breast milk

Read more

Get the app!

The Medela Family app helps you to keep track of your baby’s needs from pregnancy to nursery.


  • Pregnancy
  • Breastfeeding
  • Pumping